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How the brain is flexible enough for a complex world (without being thrown into chaos)
Every day our brains strive to optimize a trade-off: With lots of things happening around us even as we also harbor many internal drives and memories, somehow our thoughts must be flexible yet focused enough to guide everything we have to do. In a new paper in Neuron, a team of neuroscientists describes how the brain achieves the cognitive capacity to incorporate all the information that’s relevant without becoming overwhelmed by what’s not.
The brain does not multitask, said paper co-author Earl K. Miller, Picower Professor in The Picower Institute for Learning and Memory at MIT and a pioneer of the mixed selectivity idea, but many cells do have the capacity to be roped into multiple computational efforts (essentially “thoughts”). In the new paper the authors describe specific mechanisms the brain employs to recruit neurons into different computations and to ensure that those neurons represent the right number of dimensions of a complex task.
“These neurons wear multiple hats,” Miller said. “With mixed selectivity you can have a representational space that’s as complex as it needs to be and no more complex. That’s what flexible cognition is all about.”
Co-author Kay Tye, Professor at The Salk Institute and the University of California at San Diego, said mixed selectivity among neurons particularly in the medial prefrontal cortex is key to enabling many mental abilities.
“The mPFC is like a hum of whispers that represents so much information through highly flexible and dynamic ensembles,” Tye said. “Mixed selectivity is the property that endows us with our flexibility, cognitive capacity, and ability to be creative. It is the secret to maximizing computational power which is essentially the underpinnings of intelligence.”
Origins of an idea
The idea of mixed selectivity germinated in 2000 when Miller and colleague John Duncan defended a surprising result from a study of cognition in Miller’s lab. As animals sorted images into categories, about 30 percent of the neurons in the prefrontal cortex of the brain seemed to be involved. Skeptics who believed that every neuron had a dedicated function scoffed that the brain would devote so many cells to just one task. Miller and Duncan’s answer was that perhaps cells had the flexibility to be involved in many computations. The ability to serve on one cerebral task force, as it were, did not preclude them from being able to serve many others.
But what benefit does mixed selectivity convey? In 2013 Miller teamed up with two co-authors of the new paper, Mattia Rigotti of IBM Research and Stefano Fusi of Columbia University, to show how mixed selectivity endows the brain with powerful computational flexibility. Essentially, an ensemble of neurons with mixed selectivity can accommodate many more dimensions of information about a task than a population of neurons with invariant functions.
“Since our original work, we’ve made progress understanding the theory of mixed selectivity through the lens of classical machine learning ideas,” Rigotti said. “On the other hand, questions dear to experimentalists about the mechanisms implementing it at a cellular level had been comparatively under-explored. This collaboration and this new paper set out to fill that gap.”
In the new paper the authors imagine a mouse who is considering whether to eat a berry. It might smell delicious (that’s one dimension). It might be poisonous (that’s another). Yet another dimension or two of the problem could come in the form of a social cue. If the mouse smells the berry scent on a fellow mouse’s breath, then the berry is probably OK to eat (depending on the apparent health of the fellow mouse). A neural ensemble with mixed selectivity would be able to integrate all that.
Recruiting neurons
While mixed selectivity has the backing of copious evidence — it has been observed across the cortex and in other brain areas such as the hippocampus and amygdala — there are still open questions. For instance, how are neurons recruited to tasks and how do neurons that are so “open-minded” remain tuned only to what really matters to the mission?
In the new study, the researchers who also include Marcus Benna of UC San Diego and Felix Taschbach of The Salk Institute, define the forms of mixed selectivity that researchers have observed, and argue that when oscillations (also known as “brain waves”) and neuromodulators (chemicals such as serotonin or dopamine that influence neural function) recruit neurons into computational ensembles, they also help them “gate” what’s important for that purpose.
To be sure, some neurons are dedicated to a specific input, but the authors note they are an exception rather than the rule. The authors say these cells have “pure selectivity.” They only care if the rabbit sees lettuce. Some neurons exhibit “linear mixed selectivity,” which means their response predictably depends on multiple inputs adding up (the rabbit sees lettuce and feels hungry). The neurons that add the most dimensional flexibility are the “nonlinear mixed selectivity” ones that can account for multiple independent variables without necessarily summing them. Instead they might weigh a whole set of independent conditions (e.g. there’s lettuce, I’m hungry, I hear no hawks, I smell no coyotes, but the lettuce is far and I see a pretty sturdy fence).
So what brings neurons into the fold to focus on the salient factors, however many there are? One mechanism is oscillations, which are produced in the brain when many neurons all maintain their electrical activity at the same rhythm. This coordinated activity enables information sharing, essentially tuning them together like a bunch of cars all playing the same radio station (maybe the broadcast is about a hawk circling overhead). Another mechanism the authors highlight is neuromodulators. These are chemicals that upon reaching receptors within cells can influence their activity as well. A burst of acetylcholine, for instance, might similarly attune neurons with the right receptors to certain activity or information (like maybe that feeling of hunger).
“These two mechanisms likely work together to dynamically form functional networks,” the authors write.
Understanding mixed selectivity, they continue, is critical to understanding cognition.
“Mixed selectivity is ubiquitous,” they conclude. “It is present across species and across functions from high-level cognition to ‘automatic’ sensorimotor processes such as object recognition. The widespread presence of mixed selectivity underscores its fundamental role in providing the brain with the scalable processing power needed for complex thought and action.”
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Early dark energy could resolve cosmology’s two biggest puzzles
A new study by MIT physicists proposes that a mysterious force known as early dark energy could solve two of the biggest puzzles in cosmology and fill in some major gaps in our understanding of how the early universe evolved.
Now, the MIT team has found that both puzzles could be resolved if the early universe had one extra, fleeting ingredient: early dark energy. Dark energy is an unknown form of energy that physicists suspect is driving the expansion of the universe today. Early dark energy is a similar, hypothetical phenomenon that may have made only a brief appearance, influencing the expansion of the universe in its first moments before disappearing entirely.
Some physicists have suspected that early dark energy could be the key to solving the Hubble tension, as the mysterious force could accelerate the early expansion of the universe by an amount that would resolve the measurement mismatch.
The MIT researchers have now found that early dark energy could also explain the baffling number of bright galaxies that astronomers have observed in the early universe. In their new study, reported in the Monthly Notices of the Royal Astronomical Society, the team modeled the formation of galaxies in the universe’s first few hundred million years. When they incorporated a dark energy component only in that earliest sliver of time, they found the number of galaxies that arose from the primordial environment bloomed to fit astronomers’ observations.
“You have these two looming open-ended puzzles,” says study co-author Rohan Naidu, a postdoc in MIT’s Kavli Institute for Astrophysics and Space Research. “We find that in fact, early dark energy is a very elegant and sparse solution to two of the most pressing problems in cosmology.”
The study’s co-authors include lead author and Kavli postdoc Xuejian (Jacob) Shen, and MIT professor of physics Mark Vogelsberger, along with Michael Boylan-Kolchin at the University of Texas at Austin, and Sandro Tacchella at the University of Cambridge.
Big city lights
Based on standard cosmological and galaxy formation models, the universe should have taken its time spinning up the first galaxies. It would have taken billions of years for primordial gas to coalesce into galaxies as large and bright as the Milky Way.
But in 2023, NASA’s James Webb Space Telescope (JWST) made a startling observation. With an ability to peer farther back in time than any observatory to date, the telescope uncovered a surprising number of bright galaxies as large as the modern Milky Way within the first 500 million years, when the universe was just 3 percent of its current age.
“The bright galaxies that JWST saw would be like seeing a clustering of lights around big cities, whereas theory predicts something like the light around more rural settings like Yellowstone National Park,” Shen says. “And we don’t expect that clustering of light so early on.”
For physicists, the observations imply that there is either something fundamentally wrong with the physics underlying the models or a missing ingredient in the early universe that scientists have not accounted for. The MIT team explored the possibility of the latter, and whether the missing ingredient might be early dark energy.
Physicists have proposed that early dark energy is a sort of antigravitational force that is turned on only at very early times. This force would counteract gravity’s inward pull and accelerate the early expansion of the universe, in a way that would resolve the mismatch in measurements. Early dark energy, therefore, is considered the most likely solution to the Hubble tension.
Galaxy skeleton
The MIT team explored whether early dark energy could also be the key to explaining the unexpected population of large, bright galaxies detected by JWST. In their new study, the physicists considered how early dark energy might affect the early structure of the universe that gave rise to the first galaxies. They focused on the formation of dark matter halos — regions of space where gravity happens to be stronger, and where matter begins to accumulate.
“We believe that dark matter halos are the invisible skeleton of the universe,” Shen explains. “Dark matter structures form first, and then galaxies form within these structures. So, we expect the number of bright galaxies should be proportional to the number of big dark matter halos.”
The team developed an empirical framework for early galaxy formation, which predicts the number, luminosity, and size of galaxies that should form in the early universe, given some measures of “cosmological parameters.” Cosmological parameters are the basic ingredients, or mathematical terms, that describe the evolution of the universe.
Physicists have determined that there are at least six main cosmological parameters, one of which is the Hubble constant — a term that describes the universe’s rate of expansion. Other parameters describe density fluctuations in the primordial soup, immediately after the Big Bang, from which dark matter halos eventually form.
The MIT team reasoned that if early dark energy affects the universe’s early expansion rate, in a way that resolves the Hubble tension, then it could affect the balance of the other cosmological parameters, in a way that might increase the number of bright galaxies that appear at early times. To test their theory, they incorporated a model of early dark energy (the same one that happens to resolve the Hubble tension) into an empirical galaxy formation framework to see how the earliest dark matter structures evolve and give rise to the first galaxies.
“What we show is, the skeletal structure of the early universe is altered in a subtle way where the amplitude of fluctuations goes up, and you get bigger halos, and brighter galaxies that are in place at earlier times, more so than in our more vanilla models,” Naidu says. “It means things were more abundant, and more clustered in the early universe.”
“A priori, I would not have expected the abundance of JWST’s early bright galaxies to have anything to do with early dark energy, but their observation that EDE pushes cosmological parameters in a direction that boosts the early-galaxy abundance is interesting,” says Marc Kamionkowski, professor of theoretical physics at Johns Hopkins University, who was not involved with the study. “I think more work will need to be done to establish a link between early galaxies and EDE, but regardless of how things turn out, it’s a clever — and hopefully ultimately fruitful — thing to try.”
“We demonstrated the potential of early dark energy as a unified solution to the two major issues faced by cosmology. This might be an evidence for its existence if the observational findings of JWST get further consolidated,” Vogelsberger concludes. “In the future, we can incorporate this into large cosmological simulations to see what detailed predictions we get.”
This research was supported, in part, by NASA and the National Science Foundation.
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Plant-derived secondary organic aerosols can act as mediators of plant-plant interactions
A new study published in Science reveals that plant-derived secondary organic aerosols (SOAs) can act as mediators of plant-plant interactions. This research was conducted through the cooperation of chemical ecologists, plant ecophysiologists and atmospheric physicists at the University of Eastern Finland.
The study showed that Scots pine seedlings, when damaged by large pine weevils, release VOCs that activate defences in nearby plants of the same species. Interestingly, the biological activity persisted after VOCs were oxidized to form SOAs. The results indicated that the elemental composition and quantity of SOAs likely determines their biological functions.
“A key novelty of the study is the finding that plants adopt subtly different defence strategies when receiving signals as VOCs or as SOAs, yet they exhibit similar degrees of resistance to herbivore feeding,” said Professor James Blande, head of the Environmental Ecology Research Group. This observation opens up the possibility that plants have sophisticated sensing systems that enable them to tailor their defences to information derived from different types of chemical cue.
“Considering the formation rate of SOAs from their precursor VOCs, their longer lifetime compared to VOCs, and the atmospheric air mass transport, we expect that the ecologically effective distance for interactions mediated by SOAs is longer than that for plant interactions mediated by VOCs,” said Professor Annele Virtanen, head of the Aerosol Physics Research Group. This could be interpreted as plants being able to detect cues representing close versus distant threats from herbivores.
The study is expected to open up a whole new complex research area to environmental ecologists and their collaborators, which could lead to new insights on the chemical cues structuring interactions between plants.
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Folded or cut, this lithium-sulfur battery keeps going
Most rechargeable batteries that power portable devices, such as toys, handheld vacuums and e-bikes, use lithium-ion technology. But these batteries can have short lifetimes and may catch fire when damaged. To address stability and safety issues, researchers reporting in ACS Energy Letters have designed a lithium-sulfur (Li-S) battery that features an improved iron sulfide cathode. One prototype remains highly stable over 300 charge-discharge cycles, and another provides power even after being folded or cut.
The team coated iron sulfide cathodes in different polymers and found in initial electrochemical performance tests that polyacrylic acid (PAA) performed best, retaining the electrode’s discharge capacity after 300 charge-discharge cycles. Next, the researchers incorporated a PAA-coated iron sulfide cathode into a prototype battery design, which also included a carbonate-based electrolyte, a lithium metal foil as an ion source, and a graphite-based anode. They produced and then tested both pouch cell and coin cell battery prototypes.
After more than 100 charge-discharge cycles, Wang and colleagues observed no substantial capacity decay in the pouch cell. Additional experiments showed that the pouch cell still worked after being folded and cut in half. The coin cell retained 72% of its capacity after 300 charge-discharge cycles. They next applied the polymer coating to cathodes made from other metals, creating lithium-molybdenum and lithium-vanadium batteries. These cells also had stable capacity over 300 charge-discharge cycles. Overall, the results indicate that coated cathodes could produce not only safer Li-S batteries with long lifespans, but also efficient batteries with other metal sulfides, according to Wang’s team.
The authors acknowledge funding from the National Natural Science Foundation of China; the Natural Science Foundation of Sichuan, China; and the Beijing National Laboratory for Condensed Matter Physics.
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