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Implantable microphone could lead to fully internal cochlear implants

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Implantable microphone could lead to fully internal cochlear implants


Cochlear implants, tiny electronic devices that can provide a sense of sound to people who are deaf or hard of hearing, have helped improve hearing for more than a million people worldwide, according to the National Institutes of Health.

However, cochlear implants today are only partially implanted, and they rely on external hardware that typically sits on the side of the head. These components restrict users, who can’t, for instance, swim, exercise, or sleep while wearing the external unit, and they may cause others to forgo the implant altogether.

On the way to creating a fully internal cochlear implant, a multidisciplinary team of researchers at MIT, Massachusetts Eye and Ear, Harvard Medical School, and Columbia University has produced an implantable microphone that performs as well as commercial external hearing aid microphones. The microphone remains one of the largest roadblocks to adopting a fully internalized cochlear implant.

This tiny microphone, a sensor produced from a biocompatible piezoelectric material, measures miniscule movements on the underside of the ear drum. Piezoelectric materials generate an electric charge when compressed or stretched. To maximize the device’s performance, the team also developed a low-noise amplifier that enhances the signal while minimizing noise from the electronics.

While many challenges must be overcome before such a microphone could be used with a cochlear implant, the collaborative team looks forward to further refining and testing this prototype, which builds off work begun at MIT and Mass Eye and Ear more than a decade ago.

“It starts with the ear doctors who are with this every day of the week, trying to improve people’s hearing, recognizing a need, and bringing that need to us. If it weren’t for this team collaboration, we wouldn’t be where we are today,” says Jeffrey Lang, the Vitesse Professor of Electrical Engineering, a member of the Research Laboratory of Electronics (RLE), and co-senior author of a paper on the microphone.

Lang’s coauthors include co-lead authors Emma Wawrzynek, an electrical engineering and computer science (EECS) graduate student, and Aaron Yeiser SM ’21; as well as mechanical engineering graduate student John Zhang; Lukas Graf and Christopher McHugh of Mass Eye and Ear; Ioannis Kymissis, the Kenneth Brayer Professor of Electrical Engineering at Columbia; Elizabeth S. Olson, a professor of biomedical engineering and auditory biophysics at Columbia; and co-senior author Hideko Heidi Nakajima, an associate professor of otolaryngology-head and neck surgery at Harvard Medical School and Mass Eye and Ear. The research is published today in the Journal of Micromechanics and Microengineering.

Overcoming an implant impasse

Cochlear implant microphones are usually placed on the side of the head, which means that users can’t take advantage of noise filtering and sound localization cues provided by the structure of the outer ear.

Fully implantable microphones offer many advantages. But most devices currently in development, which sense sound under the skin or motion of middle ear bones, can struggle to capture soft sounds and wide frequencies.

For the new microphone, the team targeted a part of the middle ear called the umbo. The umbo vibrates unidirectionally (inward and outward), making it easier to sense these simple movements.

Although the umbo has the largest range of movement of the middle-ear bones, it only moves by a few nanometers. Developing a device to measure such diminutive vibrations presents its own challenges.

On top of that, any implantable sensor must be biocompatible and able to withstand the body’s humid, dynamic environment without causing harm, which limits the materials that can be used.

“Our goal is that a surgeon implants this device at the same time as the cochlear implant and internalized processor, which means optimizing the surgery while working around the internal structures of the ear without disrupting any of the processes that go on in there,” Wawrzynek says.

With careful engineering, the team overcame these challenges.

They created the UmboMic, a triangular, 3-millimeter by 3-millimeter motion sensor composed of two layers of a biocompatible piezoelectric material called polyvinylidene difluoride (PVDF). These PVDF layers are sandwiched on either side of a flexible printed circuit board (PCB), forming a microphone that is about the size of a grain of rice and 200 micrometers thick. (An average human hair is about 100 micrometers thick.)

The narrow tip of the UmboMic would be placed against the umbo. When the umbo vibrates and pushes against the piezoelectric material, the PVDF layers bend and generate electric charges, which are measured by electrodes in the PCB layer.

Amplifying performance

The team used a “PVDF sandwich” design to reduce noise. When the sensor is bent, one layer of PVDF produces a positive charge and the other produces a negative charge. Electrical interference adds to both equally, so taking the difference between the charges cancels out the noise.

Using PVDF provides many advantages, but the material made fabrication especially difficult. PVDF loses its piezoelectric properties when exposed to temperatures above around 80 degrees Celsius, yet very high temperatures are needed to vaporize and deposit titanium, another biocompatible material, onto the sensor. Wawrzynek worked around this problem by depositing the titanium gradually and employing a heat sink to cool the PVDF.

But developing the sensor was only half the battle — umbo vibrations are so tiny that the team needed to amplify the signal without introducing too much noise. When they couldn’t find a suitable low-noise amplifier that also used very little power, they built their own.

With both prototypes in place, the researchers tested the UmboMic in human ear bones from cadavers and found that it had robust performance within the intensity and frequency range of human speech. The microphone and amplifier together also have a low noise floor, which means they could distinguish very quiet sounds from the overall noise level.

“One thing we saw that was really interesting is that the frequency response of the sensor is influenced by the anatomy of the ear we are experimenting on, because the umbo moves slightly differently in different people’s ears,” Wawrzynek says.

The researchers are preparing to launch live animal studies to further explore this finding. These experiments will also help them determine how the UmboMic responds to being implanted.

In addition, they are studying ways to encapsulate the sensor so it can remain in the body safely for up to 10 years but still be flexible enough to capture vibrations. Implants are often packaged in titanium, which would be too rigid for the UmboMic. They also plan to explore methods for mounting the UmboMic that won’t introduce vibrations.

“The results in this paper show the necessary broad-band response and low noise needed to act as an acoustic sensor. This result is surprising, because the bandwidth and noise floor are so competitive with the commercial hearing aid microphone. This performance shows the promise of the approach, which should inspire others to adopt this concept. I would expect that smaller size sensing elements and lower power electronics would be needed for next generation devices to enhance ease of implantation and battery life issues,” says Karl Grosh, professor of mechanical engineering at the University of Michigan, who was not involved with this work.

This research was funded, in part, by the National Institutes of Health, the National Science Foundation, the Cloetta Foundation in Zurich, Switzerland, and the Research Fund of the University of Basel, Switzerland.



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Early dark energy could resolve cosmology’s two biggest puzzles

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Implantable microphone could lead to fully internal cochlear implants


A new study by MIT physicists proposes that a mysterious force known as early dark energy could solve two of the biggest puzzles in cosmology and fill in some major gaps in our understanding of how the early universe evolved.

One puzzle in question is the “Hubble tension,” which refers to a mismatch in measurements of how fast the universe is expanding. The other involves observations of numerous early, bright galaxies that existed at a time when the early universe should have been much less populated.

Now, the MIT team has found that both puzzles could be resolved if the early universe had one extra, fleeting ingredient: early dark energy. Dark energy is an unknown form of energy that physicists suspect is driving the expansion of the universe today. Early dark energy is a similar, hypothetical phenomenon that may have made only a brief appearance, influencing the expansion of the universe in its first moments before disappearing entirely.

Some physicists have suspected that early dark energy could be the key to solving the Hubble tension, as the mysterious force could accelerate the early expansion of the universe by an amount that would resolve the measurement mismatch.

The MIT researchers have now found that early dark energy could also explain the baffling number of bright galaxies that astronomers have observed in the early universe. In their new study, reported in the Monthly Notices of the Royal Astronomical Society, the team modeled the formation of galaxies in the universe’s first few hundred million years. When they incorporated a dark energy component only in that earliest sliver of time, they found the number of galaxies that arose from the primordial environment bloomed to fit astronomers’ observations.

You have these two looming open-ended puzzles,” says study co-author Rohan Naidu, a postdoc in MIT’s Kavli Institute for Astrophysics and Space Research. “We find that in fact, early dark energy is a very elegant and sparse solution to two of the most pressing problems in cosmology.”

The study’s co-authors include lead author and Kavli postdoc Xuejian (Jacob) Shen, and MIT professor of physics Mark Vogelsberger, along with Michael Boylan-Kolchin at the University of Texas at Austin, and Sandro Tacchella at the University of Cambridge.

Big city lights

Based on standard cosmological and galaxy formation models, the universe should have taken its time spinning up the first galaxies. It would have taken billions of years for primordial gas to coalesce into galaxies as large and bright as the Milky Way.

But in 2023, NASA’s James Webb Space Telescope (JWST) made a startling observation. With an ability to peer farther back in time than any observatory to date, the telescope uncovered a surprising number of bright galaxies as large as the modern Milky Way within the first 500 million years, when the universe was just 3 percent of its current age.

“The bright galaxies that JWST saw would be like seeing a clustering of lights around big cities, whereas theory predicts something like the light around more rural settings like Yellowstone National Park,” Shen says. “And we don’t expect that clustering of light so early on.”

For physicists, the observations imply that there is either something fundamentally wrong with the physics underlying the models or a missing ingredient in the early universe that scientists have not accounted for. The MIT team explored the possibility of the latter, and whether the missing ingredient might be early dark energy.

Physicists have proposed that early dark energy is a sort of antigravitational force that is turned on only at very early times. This force would counteract gravity’s inward pull and accelerate the early expansion of the universe, in a way that would resolve the mismatch in measurements. Early dark energy, therefore, is considered the most likely solution to the Hubble tension.

Galaxy skeleton

The MIT team explored whether early dark energy could also be the key to explaining the unexpected population of large, bright galaxies detected by JWST. In their new study, the physicists considered how early dark energy might affect the early structure of the universe that gave rise to the first galaxies. They focused on the formation of dark matter halos — regions of space where gravity happens to be stronger, and where matter begins to accumulate.

“We believe that dark matter halos are the invisible skeleton of the universe,” Shen explains. “Dark matter structures form first, and then galaxies form within these structures. So, we expect the number of bright galaxies should be proportional to the number of big dark matter halos.”

The team developed an empirical framework for early galaxy formation, which predicts the number, luminosity, and size of galaxies that should form in the early universe, given some measures of “cosmological parameters.” Cosmological parameters are the basic ingredients, or mathematical terms, that describe the evolution of the universe.

Physicists have determined that there are at least six main cosmological parameters, one of which is the Hubble constant — a term that describes the universe’s rate of expansion. Other parameters describe density fluctuations in the primordial soup, immediately after the Big Bang, from which dark matter halos eventually form.

The MIT team reasoned that if early dark energy affects the universe’s early expansion rate, in a way that resolves the Hubble tension, then it could affect the balance of the other cosmological parameters, in a way that might increase the number of bright galaxies that appear at early times. To test their theory, they incorporated a model of early dark energy (the same one that happens to resolve the Hubble tension) into an empirical galaxy formation framework to see how the earliest dark matter structures evolve and give rise to the first galaxies.

“What we show is, the skeletal structure of the early universe is altered in a subtle way where the amplitude of fluctuations goes up, and you get bigger halos, and brighter galaxies that are in place at earlier times, more so than in our more vanilla models,” Naidu says. “It means things were more abundant, and more clustered in the early universe.”

“A priori, I would not have expected the abundance of JWST’s early bright galaxies to have anything to do with early dark energy, but their observation that EDE pushes cosmological parameters in a direction that boosts the early-galaxy abundance is interesting,” says Marc Kamionkowski, professor of theoretical physics at Johns Hopkins University, who was not involved with the study. “I think more work will need to be done to establish a link between early galaxies and EDE, but regardless of how things turn out, it’s a clever — and hopefully ultimately fruitful — thing to try.”

We demonstrated the potential of early dark energy as a unified solution to the two major issues faced by cosmology. This might be an evidence for its existence if the observational findings of JWST get further consolidated,” Vogelsberger concludes. “In the future, we can incorporate this into large cosmological simulations to see what detailed predictions we get.”

This research was supported, in part, by NASA and the National Science Foundation.



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Plant-derived secondary organic aerosols can act as mediators of plant-plant interactions

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Implantable microphone could lead to fully internal cochlear implants


A new study published in Science reveals that plant-derived secondary organic aerosols (SOAs) can act as mediators of plant-plant interactions. This research was conducted through the cooperation of chemical ecologists, plant ecophysiologists and atmospheric physicists at the University of Eastern Finland.

It is well known that plants release volatile organic compounds (VOCs) into the atmosphere when damaged by herbivores. These VOCs play a crucial role in plant-plant interactions, whereby undamaged plants may detect warning signals from their damaged neighbours and prepare their defences. “Reactive plant VOCs undergo oxidative chemical reactions, resulting in the formation of secondary organic aerosols (SOAs). We wondered whether the ecological functions mediated by VOCs persist after they are oxidated to form SOAs,” said Dr. Hao Yu, formerly a PhD student at UEF, but now at the University of Bern.

The study showed that Scots pine seedlings, when damaged by large pine weevils, release VOCs that activate defences in nearby plants of the same species. Interestingly, the biological activity persisted after VOCs were oxidized to form SOAs. The results indicated that the elemental composition and quantity of SOAs likely determines their biological functions.

“A key novelty of the study is the finding that plants adopt subtly different defence strategies when receiving signals as VOCs or as SOAs, yet they exhibit similar degrees of resistance to herbivore feeding,” said Professor James Blande, head of the Environmental Ecology Research Group. This observation opens up the possibility that plants have sophisticated sensing systems that enable them to tailor their defences to information derived from different types of chemical cue.

“Considering the formation rate of SOAs from their precursor VOCs, their longer lifetime compared to VOCs, and the atmospheric air mass transport, we expect that the ecologically effective distance for interactions mediated by SOAs is longer than that for plant interactions mediated by VOCs,” said Professor Annele Virtanen, head of the Aerosol Physics Research Group. This could be interpreted as plants being able to detect cues representing close versus distant threats from herbivores.

The study is expected to open up a whole new complex research area to environmental ecologists and their collaborators, which could lead to new insights on the chemical cues structuring interactions between plants.



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Folded or cut, this lithium-sulfur battery keeps going

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Most rechargeable batteries that power portable devices, such as toys, handheld vacuums and e-bikes, use lithium-ion technology. But these batteries can have short lifetimes and may catch fire when damaged. To address stability and safety issues, researchers reporting in ACS Energy Letters have designed a lithium-sulfur (Li-S) battery that features an improved iron sulfide cathode. One prototype remains highly stable over 300 charge-discharge cycles, and another provides power even after being folded or cut.

Sulfur has been suggested as a material for lithium-ion batteries because of its low cost and potential to hold more energy than lithium-metal oxides and other materials used in traditional ion-based versions. To make Li-S batteries stable at high temperatures, researchers have previously proposed using a carbonate-based electrolyte to separate the two electrodes (an iron sulfide cathode and a lithium metal-containing anode). However, as the sulfide in the cathode dissolves into the electrolyte, it forms an impenetrable precipitate, causing the cell to quickly lose capacity. Liping Wang and colleagues wondered if they could add a layer between the cathode and electrolyte to reduce this corrosion without reducing functionality and rechargeability.

The team coated iron sulfide cathodes in different polymers and found in initial electrochemical performance tests that polyacrylic acid (PAA) performed best, retaining the electrode’s discharge capacity after 300 charge-discharge cycles. Next, the researchers incorporated a PAA-coated iron sulfide cathode into a prototype battery design, which also included a carbonate-based electrolyte, a lithium metal foil as an ion source, and a graphite-based anode. They produced and then tested both pouch cell and coin cell battery prototypes.

After more than 100 charge-discharge cycles, Wang and colleagues observed no substantial capacity decay in the pouch cell. Additional experiments showed that the pouch cell still worked after being folded and cut in half. The coin cell retained 72% of its capacity after 300 charge-discharge cycles. They next applied the polymer coating to cathodes made from other metals, creating lithium-molybdenum and lithium-vanadium batteries. These cells also had stable capacity over 300 charge-discharge cycles. Overall, the results indicate that coated cathodes could produce not only safer Li-S batteries with long lifespans, but also efficient batteries with other metal sulfides, according to Wang’s team.

The authors acknowledge funding from the National Natural Science Foundation of China; the Natural Science Foundation of Sichuan, China; and the Beijing National Laboratory for Condensed Matter Physics.



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