TOP SCEINCE
Common blood tests could improve cancer diagnosis for people with stomach pain or bloating
![Common blood tests could improve cancer diagnosis for people with stomach pain or bloating Common blood tests could improve cancer diagnosis for people with stomach pain or bloating](https://www.sciencedaily.com/images/scidaily-icon.png)
The results of routine blood tests could be used to speed up cancer diagnosis among people with stomach pain or bloating, suggests a new study led by UCL researchers.
The new study, published in PLOS Medicine, looked at data from more than 400,000 people aged 30 or older in the UK who had visited a GP due to stomach pain and more than 50,000 who had visited their GP due to bloating. Two thirds of this group had blood tests following their appointment.
The researchers found that, in 19 commonly used blood tests, abnormal results were linked to a higher risk of being diagnosed with cancer within a year. They estimated that, if these abnormal results were taken into account, there would have been a 16% increase in the number of people with undiagnosed cancer who were given an urgent referral, compared to assessment based on symptoms, age and sex alone.
This translates as an extra six people with undiagnosed cancer being urgently referred out of 1,000 people who had visited the GP with stomach pain or bloating, on top of 40 people with cancer being urgently referred already, without using blood test results.*
Lead author Dr Meena Rafiq, of the UCL Department of Behavioural Science & Health, said: “Our study suggests we can improve cancer detection with blood tests that are already available and that are routinely given to patients with non-specific symptoms whose cause is unclear. This could be an efficient, affordable way to improve early cancer diagnosis and in some cases increase the likelihood of successful treatment.
“Given that in practice it may be challenging for GPs to interpret a range of blood test data, our study points to the need for an automated tool that could assess cancer risk based on multiple variables.”
The study used anonymised patient data from the Clinical Practice Research Datalink (CPRD), collected from a network of GP practices across the UK between 2007 and 2016.
The researchers found that one in 50 (2.2%) people who went to the GP reporting stomach pain were diagnosed with cancer over the next 12 months. Precisely the same proportion (2.2%) of people reporting bloating were also diagnosed with cancer within a year.
In the UK, guidelines from the National Institute for Health and Care Excellence (NICE) say that people should be given an urgent cancer referral (i.e. referred to a specialist or for tests) if their risk of cancer is higher than 3%.
In the new study, the researchers found that people aged 60 or over who had gone to the GP with either stomach pain or bloating had a high enough risk to warrant an urgent cancer referral (that is, their risk was higher than 3%) regardless of blood test results. Currently, over-60s with stomach pain or bloating are only given a cancer referral in the UK if they have an additional potential cancer signal such as weight loss.
Risk of cancer was estimated to be 3.1% for men in their 60s reporting stomach pain, rising to 8.6% for men in their 80s with this symptom. For women in these age groups, the risk was 3.1%, rising to 6.1%.
The researchers cautioned that the incidence of cancer was likely to be higher in the study sample than among a broader group of people experiencing stomach pain or bloating who would not necessarily go to their GP or have blood tests.
In the UK study sample, the researchers found that, among people aged 30 to 59 years with abdominal pain or bloating, anaemia, low albumin, raised platelets, abnormal ferritin, and increased inflammatory markers strongly predicted a risk of undiagnosed cancer.
For example, in women aged 50 to 59 with abdominal bloating, pre-blood test cancer risk of 1.6% increased to 10% with raised ferritin, to 9% with low albumin, to 8% with raised platelets, to 6% with raised inflammatory markers and to 4% with anaemia.
Currently, only raised platelets and anaemia are included in guidelines for cancer referral. The guidelines, the researchers noted, focused on the presence of ‘alarm’ symptoms and risk of cancer of a single organ, with limited guidance existing for vague symptoms that could be a sign of cancer in a number of different organs.
Dr Rafiq added: “Half of all people with as-yet-undetected cancer will first go to the doctor with vague symptoms that can be challenging to diagnose. Many of these patients are investigated in primary care with commonly used blood tests that could help to identify which patients are most likely to have underlying cancer and should be prioritised for referral.
“This research shows these common tests can substantially enhance assessment of cancer risk.”
The study also showed which types of cancer were most common for people with these symptoms and how this varied depending on age and sex. Overall, bowel cancer was most common, followed by prostate and pancreatic cancer in men, while in women bowel cancer was followed by breast and ovarian cancer.
The researchers said the findings on the predictive value of blood tests for cancer could not be extrapolated to other health systems with higher or lower rates of blood test use.
The study was funded by the International Alliance for Cancer Early Detection (ACED), a partnership between UCL, Cancer Research UK (CRUK), Canary Center at Stanford University, the University of Cambridge, OHSU Knight Cancer Institute, and the University of Manchester. Additional funding came from CRUK and the National Institute of Health Research (NIHR).
* If any patient had one or more than one blood test that increased their risk to above 3% (and they would not have been referred based on their age, sex and symptom alone) they were included as an extra urgent referral.
TOP SCEINCE
Early dark energy could resolve cosmology’s two biggest puzzles
![Common blood tests could improve cancer diagnosis for people with stomach pain or bloating Common blood tests could improve cancer diagnosis for people with stomach pain or bloating](https://www.sciencedaily.com/images/scidaily-icon.png)
A new study by MIT physicists proposes that a mysterious force known as early dark energy could solve two of the biggest puzzles in cosmology and fill in some major gaps in our understanding of how the early universe evolved.
Now, the MIT team has found that both puzzles could be resolved if the early universe had one extra, fleeting ingredient: early dark energy. Dark energy is an unknown form of energy that physicists suspect is driving the expansion of the universe today. Early dark energy is a similar, hypothetical phenomenon that may have made only a brief appearance, influencing the expansion of the universe in its first moments before disappearing entirely.
Some physicists have suspected that early dark energy could be the key to solving the Hubble tension, as the mysterious force could accelerate the early expansion of the universe by an amount that would resolve the measurement mismatch.
The MIT researchers have now found that early dark energy could also explain the baffling number of bright galaxies that astronomers have observed in the early universe. In their new study, reported in the Monthly Notices of the Royal Astronomical Society, the team modeled the formation of galaxies in the universe’s first few hundred million years. When they incorporated a dark energy component only in that earliest sliver of time, they found the number of galaxies that arose from the primordial environment bloomed to fit astronomers’ observations.
“You have these two looming open-ended puzzles,” says study co-author Rohan Naidu, a postdoc in MIT’s Kavli Institute for Astrophysics and Space Research. “We find that in fact, early dark energy is a very elegant and sparse solution to two of the most pressing problems in cosmology.”
The study’s co-authors include lead author and Kavli postdoc Xuejian (Jacob) Shen, and MIT professor of physics Mark Vogelsberger, along with Michael Boylan-Kolchin at the University of Texas at Austin, and Sandro Tacchella at the University of Cambridge.
Big city lights
Based on standard cosmological and galaxy formation models, the universe should have taken its time spinning up the first galaxies. It would have taken billions of years for primordial gas to coalesce into galaxies as large and bright as the Milky Way.
But in 2023, NASA’s James Webb Space Telescope (JWST) made a startling observation. With an ability to peer farther back in time than any observatory to date, the telescope uncovered a surprising number of bright galaxies as large as the modern Milky Way within the first 500 million years, when the universe was just 3 percent of its current age.
“The bright galaxies that JWST saw would be like seeing a clustering of lights around big cities, whereas theory predicts something like the light around more rural settings like Yellowstone National Park,” Shen says. “And we don’t expect that clustering of light so early on.”
For physicists, the observations imply that there is either something fundamentally wrong with the physics underlying the models or a missing ingredient in the early universe that scientists have not accounted for. The MIT team explored the possibility of the latter, and whether the missing ingredient might be early dark energy.
Physicists have proposed that early dark energy is a sort of antigravitational force that is turned on only at very early times. This force would counteract gravity’s inward pull and accelerate the early expansion of the universe, in a way that would resolve the mismatch in measurements. Early dark energy, therefore, is considered the most likely solution to the Hubble tension.
Galaxy skeleton
The MIT team explored whether early dark energy could also be the key to explaining the unexpected population of large, bright galaxies detected by JWST. In their new study, the physicists considered how early dark energy might affect the early structure of the universe that gave rise to the first galaxies. They focused on the formation of dark matter halos — regions of space where gravity happens to be stronger, and where matter begins to accumulate.
“We believe that dark matter halos are the invisible skeleton of the universe,” Shen explains. “Dark matter structures form first, and then galaxies form within these structures. So, we expect the number of bright galaxies should be proportional to the number of big dark matter halos.”
The team developed an empirical framework for early galaxy formation, which predicts the number, luminosity, and size of galaxies that should form in the early universe, given some measures of “cosmological parameters.” Cosmological parameters are the basic ingredients, or mathematical terms, that describe the evolution of the universe.
Physicists have determined that there are at least six main cosmological parameters, one of which is the Hubble constant — a term that describes the universe’s rate of expansion. Other parameters describe density fluctuations in the primordial soup, immediately after the Big Bang, from which dark matter halos eventually form.
The MIT team reasoned that if early dark energy affects the universe’s early expansion rate, in a way that resolves the Hubble tension, then it could affect the balance of the other cosmological parameters, in a way that might increase the number of bright galaxies that appear at early times. To test their theory, they incorporated a model of early dark energy (the same one that happens to resolve the Hubble tension) into an empirical galaxy formation framework to see how the earliest dark matter structures evolve and give rise to the first galaxies.
“What we show is, the skeletal structure of the early universe is altered in a subtle way where the amplitude of fluctuations goes up, and you get bigger halos, and brighter galaxies that are in place at earlier times, more so than in our more vanilla models,” Naidu says. “It means things were more abundant, and more clustered in the early universe.”
“A priori, I would not have expected the abundance of JWST’s early bright galaxies to have anything to do with early dark energy, but their observation that EDE pushes cosmological parameters in a direction that boosts the early-galaxy abundance is interesting,” says Marc Kamionkowski, professor of theoretical physics at Johns Hopkins University, who was not involved with the study. “I think more work will need to be done to establish a link between early galaxies and EDE, but regardless of how things turn out, it’s a clever — and hopefully ultimately fruitful — thing to try.”
“We demonstrated the potential of early dark energy as a unified solution to the two major issues faced by cosmology. This might be an evidence for its existence if the observational findings of JWST get further consolidated,” Vogelsberger concludes. “In the future, we can incorporate this into large cosmological simulations to see what detailed predictions we get.”
This research was supported, in part, by NASA and the National Science Foundation.
TOP SCEINCE
Plant-derived secondary organic aerosols can act as mediators of plant-plant interactions
![Common blood tests could improve cancer diagnosis for people with stomach pain or bloating Common blood tests could improve cancer diagnosis for people with stomach pain or bloating](https://www.sciencedaily.com/images/scidaily-icon.png)
A new study published in Science reveals that plant-derived secondary organic aerosols (SOAs) can act as mediators of plant-plant interactions. This research was conducted through the cooperation of chemical ecologists, plant ecophysiologists and atmospheric physicists at the University of Eastern Finland.
The study showed that Scots pine seedlings, when damaged by large pine weevils, release VOCs that activate defences in nearby plants of the same species. Interestingly, the biological activity persisted after VOCs were oxidized to form SOAs. The results indicated that the elemental composition and quantity of SOAs likely determines their biological functions.
“A key novelty of the study is the finding that plants adopt subtly different defence strategies when receiving signals as VOCs or as SOAs, yet they exhibit similar degrees of resistance to herbivore feeding,” said Professor James Blande, head of the Environmental Ecology Research Group. This observation opens up the possibility that plants have sophisticated sensing systems that enable them to tailor their defences to information derived from different types of chemical cue.
“Considering the formation rate of SOAs from their precursor VOCs, their longer lifetime compared to VOCs, and the atmospheric air mass transport, we expect that the ecologically effective distance for interactions mediated by SOAs is longer than that for plant interactions mediated by VOCs,” said Professor Annele Virtanen, head of the Aerosol Physics Research Group. This could be interpreted as plants being able to detect cues representing close versus distant threats from herbivores.
The study is expected to open up a whole new complex research area to environmental ecologists and their collaborators, which could lead to new insights on the chemical cues structuring interactions between plants.
TOP SCEINCE
Folded or cut, this lithium-sulfur battery keeps going
![Common blood tests could improve cancer diagnosis for people with stomach pain or bloating Common blood tests could improve cancer diagnosis for people with stomach pain or bloating](https://www.sciencedaily.com/images/scidaily-icon.png)
Most rechargeable batteries that power portable devices, such as toys, handheld vacuums and e-bikes, use lithium-ion technology. But these batteries can have short lifetimes and may catch fire when damaged. To address stability and safety issues, researchers reporting in ACS Energy Letters have designed a lithium-sulfur (Li-S) battery that features an improved iron sulfide cathode. One prototype remains highly stable over 300 charge-discharge cycles, and another provides power even after being folded or cut.
The team coated iron sulfide cathodes in different polymers and found in initial electrochemical performance tests that polyacrylic acid (PAA) performed best, retaining the electrode’s discharge capacity after 300 charge-discharge cycles. Next, the researchers incorporated a PAA-coated iron sulfide cathode into a prototype battery design, which also included a carbonate-based electrolyte, a lithium metal foil as an ion source, and a graphite-based anode. They produced and then tested both pouch cell and coin cell battery prototypes.
After more than 100 charge-discharge cycles, Wang and colleagues observed no substantial capacity decay in the pouch cell. Additional experiments showed that the pouch cell still worked after being folded and cut in half. The coin cell retained 72% of its capacity after 300 charge-discharge cycles. They next applied the polymer coating to cathodes made from other metals, creating lithium-molybdenum and lithium-vanadium batteries. These cells also had stable capacity over 300 charge-discharge cycles. Overall, the results indicate that coated cathodes could produce not only safer Li-S batteries with long lifespans, but also efficient batteries with other metal sulfides, according to Wang’s team.
The authors acknowledge funding from the National Natural Science Foundation of China; the Natural Science Foundation of Sichuan, China; and the Beijing National Laboratory for Condensed Matter Physics.
-
Solar Energy3 years ago
DLR testing the use of molten salt in a solar power plant in Portugal
-
Camera1 year ago
DJI Air 3 vs. Mini 4 Pro: which compact drone is best?
-
world news1 year ago
Gulf, France aid Gaza, Russia evacuates citizens
-
Indian Defense3 years ago
Israeli Radar Company Signs MoU To Cooperate With India’s Alpha Design Technologies
-
Camera1 year ago
Sony a9 III: what you need to know
-
Solar Energy1 year ago
Glencore eyes options on battery recycling project
-
Camera4 years ago
Charles ‘Chuck’ Geschke, co-founder of Adobe and inventor of the PDF, dies at 81
-
world news1 year ago
Strong majority of Americans support Israel-Hamas hostage deal