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Birdsong and human voice built from same genetic blueprint

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Birdsong and human voice built from same genetic blueprint


Humans have been long fascinated by bird song and the cacophony of other avian sounds — from coos and honks to quacks and peeps. But little is known about how the unique vocal organ of birds — the syrinx — varies from species to species or its deeper evolutionary origins.

A trio of recent studies led by researchers from The University of Texas at Austin is changing that.

The studies include high-resolution anatomical scans of syrinxes from hummingbirds and ostriches — the world’s smallest and largest bird species — and the discovery that the syrinx and larynx, the vocal organ of reptiles and mammals, including humans, share the same developmental programming.

According to Julia Clarke, a professor at UT’s Jackson School of Geosciences, this genetic connection between the vocal organs is an exciting new example of “deep homology,” a term that describes how different tissues or organs can share a common genetic link.

“To me, this is as big as the flippers-to-limbs transition,” said Clarke, who co-led or co-authored the studies. “In some ways, it’s even bigger because the syrinx is not a modified organ with a new function but a completely new one with an ancient and common function.”

The three studies are built on a foundation of collaborative and interdisciplinary syrinx research with physiologists and developmental biologists that Clarke has been leading for over a decade. The research got its start in 2013 when Clarke, a paleontologist, discovered a syrinx in a fossil of a duck-like bird that lived in what is now Antarctica during the Late Cretaceous. The specimen is the oldest syrinx to be discovered. But when she tried to compare the fossil syrinx to the syrinxes of modern birds, she found the scientific literature lacking. Many of the studies dated back to the 19th century, before the advent of modern scientific imaging, or cited claims from those older studies made without double-checking them.

This set Clarke on a mission to modernize — and maximize — syrinx data collection.

“We had this new three-dimensional structure, but we had nothing to compare it to,” said Clarke, describing CT imaging data of the fossil syrinx. “So, we started generating data that did not previously exist on syrinx structure across many different groups of birds.”

Over the years, Clarke and members of her lab have developed new methods for dissecting, preserving and CT-scanning syrinxes that have helped reveal the syrinx in more detail. These enhanced views of the ostrich and hummingbird vocal organ have shown that bird behavior may be just as important as the syrinx when it comes to the repertoire of sounds these birds produce.

For example, in the study of the ostrich syrinx, the researchers found no significant differences in syrinx anatomy between adult male and female birds (previous studies focused only on male ostriches.) However, even though both sexes have the same vocal equipment, male ostriches tended to make a wider variety of sounds than female ostriches, with the sounds often associated with aggressive behaviors between rowdy males. On a visit to a Texas ostrich farm, the researchers recorded 11 types of calls, ranging from high frequency peeps and gurgles in baby ostriches to low frequency boos and booms in adult males. These included a few call types that had never been recorded before. The only sounds definitively recorded from adult female ostriches were hisses. What the females lacked in range, they made up for in attitude said Michael Chiappone, who became involved with the ostrich research as an undergraduate student at the Jackson School and is the lead author of the study.

“They were quite prolific hissers,” said Chiappone, who is now a doctoral student at the University of Minnesota.

For the hummingbird study, the researchers compared the hummingbird syrinx to the syrinx of swifts and nightjars, two close relatives, and found that all three birds have similar vocal folds in their syrinx despite having different ways of learning their calls. Swifts and nightjars work with a limited repertoire of instinctive calls while hummingbirds are able to elaborate on calls by learning complex songs from each other, a trait called vocal learning.

According to Lucas Legendre, a Jackson School research associate who led the hummingbird research, the findings suggest that the common ancestor of all three birds also had a similar vocal fold structure — and that it may have helped lay the groundwork for the evolution in vocal learning in hummingbirds.

“Having all of the [vocal fold] structures already present before vocal learning was acquired by hummingbirds probably made it easier for them to acquire vocal production learning,” he said.

Before the study, it was uncertain if swifts even had vocal folds. As part of the research, Legendre created a 3D digital model of the swift vocal track that takes viewers down the windpipe to the syrinx and to the vocal folds that rest near the top of each branch of the syrinx. The model — dubbed the “magical mystery voyage” by Clarke — shows the advances in anatomical knowledge of syrinx that her lab is leading.

“This is a structure that wasn’t known to exist outside of hummingbirds, but our CT scans revealed that swifts have these vocal folds in the same position,” Clarke said. “This is the kind of voyage we needed to go on to get these answers.”

At the same time Clarke and her team were developing methods to preserve and capture syrinx anatomy across bird species, they were collaborating with Clifford Tabin, a developmental biologist at Harvard University, on investigating the evolutionary origins of the syrinx by tracking the gene expression that accompanied vocal organ development in the embryos of birds, mammals and reptiles.

The research published in Current Biology is a culmination of that collaboration. The study details how scientists discovered the deep connection between the larynx and the syrinx tissues by observing that the same genes were controlling the development of the vocal organs in mice and chicken embryos, respectively, even though the organs arose from different embryological layers.

“They form under the influence of the same genetic pathways, ultimately giving the vocal tissue similar cellular structure and vibratory properties in birds and mammals,” said Tabin, a co-lead on the study.

The study also analyzed syrinx development across bird species — which involved observing gene expression in embryos from 14 different species, from penguins to budgies — and found that the common ancestor of modern birds probably had a syrinx with two sound sources, or two independently functioning vocal folds. This trait is found in songbirds today, allowing many to create two distinct sounds at the same time. The research suggests that that the common ancestor of birds may have been making similarly diverse calls.

These results may shed light on the syrinx’s origins but it’s still unknown when the syrinx first developed and whether non-avian dinosaurs — the ancestors of today’s birds — had the vocal organ, said Clarke. No one has yet found a fossil syrinx from a non-avian dinosaur.

According to Clarke, the best way to understand the possibilities for ancient dinosaur sounds is to continue studying vocalization as it exists today in birds, the dinosaurs that are still with us, and other reptile cousins.

“We can’t start talking about sound production in dinosaurs until we truly understand the system in living species,” she said.

This research was supported by the Gordon and Betty Moore Foundation, Howard Hughes Medical InstituteProfessors Program and the Jackson School of Geosciences. Chad Eliason, a senior research scientist at the Field Museum of Natural History and former postdoctoral scholar at the Jackson School, was also a major contributor to these syrinx projects and others.



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Early dark energy could resolve cosmology’s two biggest puzzles

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Birdsong and human voice built from same genetic blueprint


A new study by MIT physicists proposes that a mysterious force known as early dark energy could solve two of the biggest puzzles in cosmology and fill in some major gaps in our understanding of how the early universe evolved.

One puzzle in question is the “Hubble tension,” which refers to a mismatch in measurements of how fast the universe is expanding. The other involves observations of numerous early, bright galaxies that existed at a time when the early universe should have been much less populated.

Now, the MIT team has found that both puzzles could be resolved if the early universe had one extra, fleeting ingredient: early dark energy. Dark energy is an unknown form of energy that physicists suspect is driving the expansion of the universe today. Early dark energy is a similar, hypothetical phenomenon that may have made only a brief appearance, influencing the expansion of the universe in its first moments before disappearing entirely.

Some physicists have suspected that early dark energy could be the key to solving the Hubble tension, as the mysterious force could accelerate the early expansion of the universe by an amount that would resolve the measurement mismatch.

The MIT researchers have now found that early dark energy could also explain the baffling number of bright galaxies that astronomers have observed in the early universe. In their new study, reported in the Monthly Notices of the Royal Astronomical Society, the team modeled the formation of galaxies in the universe’s first few hundred million years. When they incorporated a dark energy component only in that earliest sliver of time, they found the number of galaxies that arose from the primordial environment bloomed to fit astronomers’ observations.

You have these two looming open-ended puzzles,” says study co-author Rohan Naidu, a postdoc in MIT’s Kavli Institute for Astrophysics and Space Research. “We find that in fact, early dark energy is a very elegant and sparse solution to two of the most pressing problems in cosmology.”

The study’s co-authors include lead author and Kavli postdoc Xuejian (Jacob) Shen, and MIT professor of physics Mark Vogelsberger, along with Michael Boylan-Kolchin at the University of Texas at Austin, and Sandro Tacchella at the University of Cambridge.

Big city lights

Based on standard cosmological and galaxy formation models, the universe should have taken its time spinning up the first galaxies. It would have taken billions of years for primordial gas to coalesce into galaxies as large and bright as the Milky Way.

But in 2023, NASA’s James Webb Space Telescope (JWST) made a startling observation. With an ability to peer farther back in time than any observatory to date, the telescope uncovered a surprising number of bright galaxies as large as the modern Milky Way within the first 500 million years, when the universe was just 3 percent of its current age.

“The bright galaxies that JWST saw would be like seeing a clustering of lights around big cities, whereas theory predicts something like the light around more rural settings like Yellowstone National Park,” Shen says. “And we don’t expect that clustering of light so early on.”

For physicists, the observations imply that there is either something fundamentally wrong with the physics underlying the models or a missing ingredient in the early universe that scientists have not accounted for. The MIT team explored the possibility of the latter, and whether the missing ingredient might be early dark energy.

Physicists have proposed that early dark energy is a sort of antigravitational force that is turned on only at very early times. This force would counteract gravity’s inward pull and accelerate the early expansion of the universe, in a way that would resolve the mismatch in measurements. Early dark energy, therefore, is considered the most likely solution to the Hubble tension.

Galaxy skeleton

The MIT team explored whether early dark energy could also be the key to explaining the unexpected population of large, bright galaxies detected by JWST. In their new study, the physicists considered how early dark energy might affect the early structure of the universe that gave rise to the first galaxies. They focused on the formation of dark matter halos — regions of space where gravity happens to be stronger, and where matter begins to accumulate.

“We believe that dark matter halos are the invisible skeleton of the universe,” Shen explains. “Dark matter structures form first, and then galaxies form within these structures. So, we expect the number of bright galaxies should be proportional to the number of big dark matter halos.”

The team developed an empirical framework for early galaxy formation, which predicts the number, luminosity, and size of galaxies that should form in the early universe, given some measures of “cosmological parameters.” Cosmological parameters are the basic ingredients, or mathematical terms, that describe the evolution of the universe.

Physicists have determined that there are at least six main cosmological parameters, one of which is the Hubble constant — a term that describes the universe’s rate of expansion. Other parameters describe density fluctuations in the primordial soup, immediately after the Big Bang, from which dark matter halos eventually form.

The MIT team reasoned that if early dark energy affects the universe’s early expansion rate, in a way that resolves the Hubble tension, then it could affect the balance of the other cosmological parameters, in a way that might increase the number of bright galaxies that appear at early times. To test their theory, they incorporated a model of early dark energy (the same one that happens to resolve the Hubble tension) into an empirical galaxy formation framework to see how the earliest dark matter structures evolve and give rise to the first galaxies.

“What we show is, the skeletal structure of the early universe is altered in a subtle way where the amplitude of fluctuations goes up, and you get bigger halos, and brighter galaxies that are in place at earlier times, more so than in our more vanilla models,” Naidu says. “It means things were more abundant, and more clustered in the early universe.”

“A priori, I would not have expected the abundance of JWST’s early bright galaxies to have anything to do with early dark energy, but their observation that EDE pushes cosmological parameters in a direction that boosts the early-galaxy abundance is interesting,” says Marc Kamionkowski, professor of theoretical physics at Johns Hopkins University, who was not involved with the study. “I think more work will need to be done to establish a link between early galaxies and EDE, but regardless of how things turn out, it’s a clever — and hopefully ultimately fruitful — thing to try.”

We demonstrated the potential of early dark energy as a unified solution to the two major issues faced by cosmology. This might be an evidence for its existence if the observational findings of JWST get further consolidated,” Vogelsberger concludes. “In the future, we can incorporate this into large cosmological simulations to see what detailed predictions we get.”

This research was supported, in part, by NASA and the National Science Foundation.



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Plant-derived secondary organic aerosols can act as mediators of plant-plant interactions

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Birdsong and human voice built from same genetic blueprint


A new study published in Science reveals that plant-derived secondary organic aerosols (SOAs) can act as mediators of plant-plant interactions. This research was conducted through the cooperation of chemical ecologists, plant ecophysiologists and atmospheric physicists at the University of Eastern Finland.

It is well known that plants release volatile organic compounds (VOCs) into the atmosphere when damaged by herbivores. These VOCs play a crucial role in plant-plant interactions, whereby undamaged plants may detect warning signals from their damaged neighbours and prepare their defences. “Reactive plant VOCs undergo oxidative chemical reactions, resulting in the formation of secondary organic aerosols (SOAs). We wondered whether the ecological functions mediated by VOCs persist after they are oxidated to form SOAs,” said Dr. Hao Yu, formerly a PhD student at UEF, but now at the University of Bern.

The study showed that Scots pine seedlings, when damaged by large pine weevils, release VOCs that activate defences in nearby plants of the same species. Interestingly, the biological activity persisted after VOCs were oxidized to form SOAs. The results indicated that the elemental composition and quantity of SOAs likely determines their biological functions.

“A key novelty of the study is the finding that plants adopt subtly different defence strategies when receiving signals as VOCs or as SOAs, yet they exhibit similar degrees of resistance to herbivore feeding,” said Professor James Blande, head of the Environmental Ecology Research Group. This observation opens up the possibility that plants have sophisticated sensing systems that enable them to tailor their defences to information derived from different types of chemical cue.

“Considering the formation rate of SOAs from their precursor VOCs, their longer lifetime compared to VOCs, and the atmospheric air mass transport, we expect that the ecologically effective distance for interactions mediated by SOAs is longer than that for plant interactions mediated by VOCs,” said Professor Annele Virtanen, head of the Aerosol Physics Research Group. This could be interpreted as plants being able to detect cues representing close versus distant threats from herbivores.

The study is expected to open up a whole new complex research area to environmental ecologists and their collaborators, which could lead to new insights on the chemical cues structuring interactions between plants.



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Folded or cut, this lithium-sulfur battery keeps going

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Birdsong and human voice built from same genetic blueprint


Most rechargeable batteries that power portable devices, such as toys, handheld vacuums and e-bikes, use lithium-ion technology. But these batteries can have short lifetimes and may catch fire when damaged. To address stability and safety issues, researchers reporting in ACS Energy Letters have designed a lithium-sulfur (Li-S) battery that features an improved iron sulfide cathode. One prototype remains highly stable over 300 charge-discharge cycles, and another provides power even after being folded or cut.

Sulfur has been suggested as a material for lithium-ion batteries because of its low cost and potential to hold more energy than lithium-metal oxides and other materials used in traditional ion-based versions. To make Li-S batteries stable at high temperatures, researchers have previously proposed using a carbonate-based electrolyte to separate the two electrodes (an iron sulfide cathode and a lithium metal-containing anode). However, as the sulfide in the cathode dissolves into the electrolyte, it forms an impenetrable precipitate, causing the cell to quickly lose capacity. Liping Wang and colleagues wondered if they could add a layer between the cathode and electrolyte to reduce this corrosion without reducing functionality and rechargeability.

The team coated iron sulfide cathodes in different polymers and found in initial electrochemical performance tests that polyacrylic acid (PAA) performed best, retaining the electrode’s discharge capacity after 300 charge-discharge cycles. Next, the researchers incorporated a PAA-coated iron sulfide cathode into a prototype battery design, which also included a carbonate-based electrolyte, a lithium metal foil as an ion source, and a graphite-based anode. They produced and then tested both pouch cell and coin cell battery prototypes.

After more than 100 charge-discharge cycles, Wang and colleagues observed no substantial capacity decay in the pouch cell. Additional experiments showed that the pouch cell still worked after being folded and cut in half. The coin cell retained 72% of its capacity after 300 charge-discharge cycles. They next applied the polymer coating to cathodes made from other metals, creating lithium-molybdenum and lithium-vanadium batteries. These cells also had stable capacity over 300 charge-discharge cycles. Overall, the results indicate that coated cathodes could produce not only safer Li-S batteries with long lifespans, but also efficient batteries with other metal sulfides, according to Wang’s team.

The authors acknowledge funding from the National Natural Science Foundation of China; the Natural Science Foundation of Sichuan, China; and the Beijing National Laboratory for Condensed Matter Physics.



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